Conversion of biomass assets into 5-hydroxymethylfurfural (5-HMF) is of nice significance for the valorization of biomass into key chemical compounds and fuels. Nonetheless, designing of heterogeneous catalysts with controllable Brønsted and Lewis acid websites for attaining excessive yields of 5-HMF nonetheless stays a problem. Herein, extremely environment friendly SAPO-34 nanocrystallites catalyst has been synthesized by a facile technique, using business low-cost organosilane [3-glycidoxypropyltrimethoxysilane (AC-230)] along with seeds and microporous template triethylamine. The advanced functionalities of AC-230 had been investigated by conditional experiments and systematic characterizations. The resultant SAPO-34 nanocrystallites (SP-MS) course of ultra-high exterior floor space (180 m2/g) and enormous mesopore quantity (0.51 cm3/g), excessive quantity of accessible Brønsted/Lewis acid and good hydrophilicity. For the conversion of mono-, di- and poly-saccharides into 5-HMF, SP-MS exhibited outstanding exercise. Usually, 81% yield of 5-HMF with an entire glucose conversion was achieved in a biphasic NaCl-H2O/methyl isobutyl ketone solvent system at 170 °C inside 45 min, clearly higher than different heterogeneous acid-catalysts. The kinetic examine confirmed that the plentiful Lewis acid websites over the SP-MS decreased the obvious activation vitality (85 kJ/mol) of glucose isomerization, after which boosted the 5-HMF yields within the presence of reasonable Brønsted acid websites. Extra attractively, the catalytic exercise will be restored at the least after 4 cycles. The current work is anticipated to offer insights into designing environment friendly and sturdy SAPO catalysts for the 5-HMF manufacturing.