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Tuesday, June 6, 2023

Winners of the 2022 Cardio-Oncology Journal Prize

The First Worldwide Pediatric Cardio-Oncology Assembly was held on October 21-22, 2022 in Cincinnati, OH. Plenty of authentic analysis scientific abstracts have been acquired following a world name for submissions for innovative cardio-oncology analysis. All summary submissions have been critically reviewed by members of the convention’s organizing committee. 4 submitted abstracts acquired the best scores for important scientific contributions to this discipline. These 4 have been introduced from the platform on the assembly as oral shows and have been awarded the “Cardio-Oncology Journal Prize” for high authentic analysis posters. Right here, the winners present particulars on their analysis.

Be aware from Prof. Steven Lipshultz, Editor-in-Chief of Cardio-Oncology, and Miriam Mestre, Managing Editor. This inaugural convention was collectively sponsored by Sofia’s Hope, the Cincinnati Kids’s Coronary heart Institute, and Oishei Kids’s Hospital/Jacobs College of Drugs and Biomedical Sciences, College at Buffalo. The “Cardio-Oncology Journal Prize” for high authentic analysis posters was sponsored by BMC. The Steering Committee was comprised of world-renowned leaders in cardio-oncology and the assembly introduced collectively thought-leaders, practitioners, and advocates within the discipline of pediatric cardio-oncology for a uniquely targeted session. Plans are at present underway for the following convention in 2024.

Christina Yang, College of Washington-Seattle Kids’s Hospital, USA
Summary: “Machine Studying has Potential to Help in Identification of Kids at Excessive Danger for Remedy-Associated Cardiomyopathy by means of Echocardiography”
I’m a 3rd yr pediatric resident on the College of Washington-Seattle Kids’s Hospital and am planning to start out a fellowship in Pediatric Cardiology at Kids’s Nationwide Hospital submit residency. I’ve a background in Biomedical Engineering previous to medical college and a specific curiosity in world well being and healthcare in resource-limited settings. My analysis in pediatric cardiology has beforehand targeted on learning targeted-view echocardiogram for screening sure cardiac circumstances, with the aim to ultimately use AI for cardiac screening in resource-limited settings.

On this undertaking, I collaborated with schools from the Division of Cardiology, Fred Hutchinson Most cancers Analysis Heart, and the College of Washington Division of Bioengineering Cardiac System Stimulation Lab, and recognized echocardiographic imaging clips in numerous views used for analysis of cardiomyopathy in youngsters present process chemotherapy, and labored with the engineering staff to develop a machine studying mannequin with the aim of serving to predict cardiomyopathy in childhood most cancers survivors. My plan is to proceed my analysis in machine studying and AI, and additional apply this idea to enhance cardiac screening in world in addition to resource-limited settings.

Elizabeth (Lieke) A.M. Feijen-Allenstein, Princess Máxima Heart for Pediatric Oncology, the Netherlands
Summary: “Detection of irregular values of cardiac perform and related markers in childhood most cancers survivors: a cross-sectional examine”
Most cancers therapy-related coronary heart dysfunction are main issues in long-term childhood most cancers survivors. This examine assessed the incidence of irregular coronary heart perform, EKG markers and blood markers in survivors in comparison with siblings. We invited 1291 survivors handled with most cancers remedy that impacts the center and 271 siblings to the outpatient clinic to carry out an echo of the center, EKG, and draw blood for blood markers. The incidence of irregular coronary heart perform and irregular blood markers is excessive in survivors and occurred rather more in survivors than in siblings.

I’m a senior well being scientist within the Princess Máxima Heart for Pediatric Oncology. My mission is to extend information on cardiotoxicity in youngsters with and after most cancers, and on the overall burden of illness in survivors after childhood most cancers and to information younger PhD college students of their careers.

Elvira van Dalen, Princess Máxima Heart for Pediatric Oncology, the Netherlands
Summary: “Main cardioprotection with dexrazoxane in childhood most cancers sufferers anticipated to obtain anthracyclines: suggestions from the Worldwide Late Results of Childhood Most cancers Guideline Harmonization Group”
I’m a senior scientific scientist/epidemiologist on the Princess Máxima Heart for Pediatric Oncology in Utrecht, the Netherlands. My curiosity in cardiotoxicity after childhood most cancers remedy began with an internship throughout my medical coaching, when just a little woman was admitted to the ICU due to extreme coronary heart failure throughout her most cancers remedy. This made the issue very actual for me. I continued working on this discipline and I did my PhD thesis on anthracycline-induced cardiotoxicity throughout and after remedy for childhood most cancers. My most important analysis pursuits now are late results after childhood most cancers remedy, with a particular deal with heart problems, and systematic opinions and tips within the pediatric oncology discipline.

Through the convention I introduced the Worldwide Late Results of Childhood Most cancers Guideline Harmonization Group (IGHG) guideline on cardio-protection with dexrazoxane in childhood most cancers sufferers who’re anticipated to obtain anthracyclines. Little steerage was out there on its use in youngsters. Due to this fact, a staff of worldwide specialists reviewed the prevailing literature and used evidence-based methodology to formulate suggestions. We concluded that the advantages of dexrazoxane most likely outweigh the danger of subsequent neoplasms when the cumulative doxorubicin or equal dose is ≥250 mg/m2 (average advice). Nonetheless, there was inadequate proof to make a advice for decrease doses and we encourage additional analysis. The rule acquired enthusiastic responses from the viewers and it has been an honor to be chosen as one of many high abstracts. I’m very proud that the rule of thumb now has been printed in Lancet Youngster & Adolescent Well being. Hopefully it would assist stop or scale back anthracycline-induced cardiotoxicity for a lot of childhood most cancers sufferers.

Takeshi Tsuda, Nemours Kids’s Hospital Delaware; Thomas Jefferson College, USA
Summary: “Surveillance Cardiopulmonary Train Testing Can Determine Childhood Most cancers Survivors: Who’re at Danger for Lengthy-Time period Cardiovascular Problems?”
Though survival after childhood most cancers remedy has considerably improved in recent times, long-term cardiovascular problems have turn out to be a serious concern in childhood most cancers survivors. The power cardiovascular illnesses are often insidious however pervasive and progressive, and early subclinical adjustments are tough to determine in youngsters. We’ve proposed a singular technique in analyzing cardiopulmonary testing (CPET) as a helpful screening software to determine early irregular adjustments in these sufferers. With this technique, we have been capable of determine the contributing mechanisms, together with decreased skeletal muscle mass, decreased stroke quantity reserve, impaired muscle metabolism, and inefficient respiratory sample, in childhood most cancers survivors. Bodily conditioning and cardiovascular reserve are two mutually dependent elements that closely affect future cardiovascular well being and normal wellness. We imagine CPET is a helpful screening technique to determine subclinical cardiovascular abnormalities in childhood most cancers survivors. With this strategy, we will sufficiently tackle the mechanisms of the subclinical adjustments often seen in these sufferers. Train shouldn’t be solely a technique to assess cardiopulmonary reserve, but in addition an vital therapeutic modality to reinforce their future well being resilience.

I’m a senior pediatric heart specialist at Nemours Kids’s Well being Delaware. Presently I’ve been specializing in CPET and train physiology to evaluate cardiovascular reserve in sufferers with and with out sure cardiac circumstances. I’m resulting in construct up the cardio-oncology program in our hospital by which early subclinical cardiovascular abnormality will likely be recognized by means of multidisciplinary strategy together with routine CPET. We additionally emphasize the significance of training for these youngsters to grasp a fundamental idea of human well being (weight loss program, diet, train, and sleep) and to foster their duty, independence, and confidence for his or her future well being. I function a Professor of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson College and have been concerned in medical training and analysis mentorship.

A number of years in the past, I encountered three consecutive CPET circumstances the place three adolescents with historical past of most cancers remedy confirmed surprisingly poor train efficiency even if they have been famous as asymptomatic with regular cardiac efficiency by echocardiogram. I used to be satisfied that that is the inhabitants that had not been acknowledged as vulnerable to future heart problems. As I studied extra about chemotherapy-mediated cardiotoxicity, I used to be fascinated by the complexity of the issue regardless of the depth of scientific endeavors to grasp the mechanisms. On the identical time, I spotted that these in any other case unidentified sufferers could proceed to exacerbate their underlying cardiac standing to progress to superior coronary heart illness.


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